Extended DMT Pen Use Found Safe for Anxiety Relief

Q: How do I use a DMT pen?

Charge Your Pen. Make sure the vape pen is fully charged. Prepare. Choose a safe and comfortable place, ideally with someone sober with you. Load DMT. If needed, put DMT into the pen’s heating chamber. Turn On the Pen. Usually, pressing the power button five times activates the pen. Set Temperature. Set the temperature suitable for DMT (around 140°C to 160°C) if possible. Inhale. Take a slow inhale, hold the vapour for about 10-15 seconds, then exhale. Repeat as Desired: Depending on your experience, you may or may not take more hits. Turn Off and Clean: Always turn off the pen after use and clean it as instructed.

DMT is a powerful psychedelic substance found naturally in various plants and animals. It is also produced in small amounts in the human body. Known for its short but intense psychoactive effects, DMT pen induces perception, cognition, and mood changes.

Recent research suggests its potential therapeutic effects in treating mental health disorders, including anxiety. However, concerns about its safety and the potential risks associated with prolonged use have led to a closer examination of its tolerability in clinical settings.

Clinical Insights Report Extended Use of DMT Pen is Tolerable For Individuals With Anxiety

What is DMT?

N, N-dimethyltryptamine (DMT) is a serotonergic hallucinogen found in certain plants used in ayahuasca, a psychoactive brew used socially and ceremonially by indigenous peoples in the Amazon.

When ingested orally, the psychedelic drug DMT is rapidly metabolized by monoamine oxidase inhibitors (MAOIs) to an inactive form. However, intravenous administration bypasses this process. This results in brief but intense effects compared to other psychedelics like psilocybin or ayahuasca.

Scholars have examined this compound, as it elicits immersive experiences characterized by vivid imagery and somatosensory, affective, and cognitive effects.

The Extended DMT Experience

While the acute effects of DMT usually last for 15-30 minutes when smoked or injected, there are methods to extend its duration for therapeutic purposes. These methods include:

Oral Administration

Consuming DMT orally in the form of ayahuasca, a traditional Amazonian brew, prolongs the duration of its effects to several hours. Ayahuasca contains DMT along with a monoamine oxidase inhibitor (MAOI) that allows DMT to be orally active.

Infusion Therapy

Intravenous infusion of DMT in controlled clinical settings allows for a more gradual onset and longer duration of effects compared to smoking or injection. This method enables clinicians to tailor the experience to the individual’s needs.

Other Clinical Research Findings

Clinical research on the extended use of DMT for anxiety is still in its early stages, but initial findings have interesting results.

Department of Brain Sciences, Imperial College London (2023)

Researchers conducted a placebo-controlled study investigating a novel method of DMT integration involving a bolus injection paired with a constant-rate infusion to prolong the DMT experience.

Using pharmacokinetic parameters, dose regimens were developed to maintain steady levels of immersion in the DMT experience over 30 minutes. Four doses were tested on 11 healthy volunteers.

The results demonstrate that this method effectively extends the DMT experience in a stable and tolerable manner. Throughout the active infusion, subjects reported sustained subjective effects with low anxiety ratings and heart rates stabilizing within 15 minutes, indicating psychological and physiological safety.

Department of Psychiatry, Yale University School of Medicine (2022)

Researchers from Yale, VA Connecticut Healthcare System, and the University of Wisconsin School of Medicine and Public Health utilized a fixed-order, dose-escalation approach with minimal psychotherapy in a hospital setting.

The study has 7 treatment-resistant MDD participants and 3 healthy controls. Participants received intravenous DMT in escalating doses (0.1 mg/kg followed by 0.3 mg/kg). Various parameters, including cardiovascular function, abuse liability, psychedelic and psychotomimetic effects, mood, and anxiety, were assessed during each dosing session.

Results:

Healthy controls and MDD participants tolerated DMT administration well, with no dropouts reported.
In MDD participants, significant reductions in HAMD-17 scores were observed the day after receiving 0.3 mg/kg DMT.
Adverse events were mostly mild, with one serious event that resolved independently.
DMT led to temporary increases in blood pressure, heart rate, anxiety, psychedelic effects, and psychotomimetic effects, which subsided within 20-30 minutes post-injection.

Johns Hopkins School of Medicine, Baltimore (2019)

Self-reported changes in depression and anxiety among individuals using 5-MeO-DMT in group settings with structured procedures governing dose and administration were observed. A total of 362 respondents completed an anonymous web-based survey.

Results:

Among those diagnosed with depression (41%) or anxiety (48%), a majority reported improvement in their conditions following 5-MeO-DMT use (depression = 80%; anxiety = 79%).
Fewer individuals reported no change (depression = 17%; anxiety = 19%) or worsening (depression = 3%; anxiety = 2%) of their symptoms.
Improvement in depression and anxiety was integrated into stronger unexplainable experiences and higher ratings of the spiritual significance and personal preferences of the 5-MeO-DMT experience.
There were no significant associations between improvement in depression or anxiety and the intensity of acute challenging physical or psychological effects during the 5-MeO-DMT experience.

DMT’s Other Potential Therapeutic Uses

Apart from its potential for treating anxiety, DMT also holds promise for addressing various mental health conditions, including depression, post-traumatic stress disorder (PTSD), and substance use disorders. DMT’s unique pharmacological properties, characterized by its rapid onset and short duration, make it an invaluable tool in psychotherapeutic interventions.

Depression

New research suggests that DMT could be a therapeutic option for depression. Initial studies indicate that DMT use might quickly improve mood and overall well-being. Further exploration of DMT’s antidepressant effects could lead to more studies and trials focusing on its effectiveness and safety in managing depressive symptoms.

Post-Traumatic Stress Disorder (PTSD)

DMT’s pharmacological profile and psychoactive effects also make it an efficient treatment for post-traumatic stress disorder (PTSD). DMT’s ability to induce significant changes in consciousness may help with processing and integrating traumatic memories. Although research in this area is still early, early findings suggest that DMT-assisted therapy could be a promising part of comprehensive treatment plans for individuals dealing with PTSD.

Substance Use Disorders

DMT’s therapeutic potential extends to substance use disorders, offering a different approach to addiction treatment. Studies investigating DMT-assisted therapy for substance abuse have shown interesting results.

These DMT sessions have helped individuals gain insights, introspect, and become more self-aware, which could aid in overcoming addictive behaviours. By facilitating deep psychological experiences, DMT shows promise in encouraging lasting changes in behaviour and supporting recovery from substance use disorders.

Comparison with Traditional Treatments for Anxiety

Selective Serotonin Reuptake Inhibitors (SSRIs)

While SSRIs are commonly prescribed for anxiety disorders, they usually require weeks or months to exert their full therapeutic effects. They may be associated with minimal side effects such as sexual dysfunction and weight gain. In contrast, DMT has a rapid onset of action and may produce profound therapeutic effects after a single dose.

Cognitive-Behavioural Therapy (CBT)

CBT is a widely used psychotherapeutic approach for anxiety disorders, focusing on identifying and modifying maladaptive thought patterns and behaviours. DMT-assisted therapy may complement CBT by facilitating emotional processing, enhancing introspection, and promoting insight into the underlying causes of anxiety.

See the DMT Vape Pen Carts Collection

Product	Lucid Supply Co. – N,N-DMT Vaporizer	Lucid Supply Co. – 5-MeO DMT Vaporizer	Deadhead Chemist – 5-MeO-DMT (Cartridge)
Active Ingredient	N,N-Dimethyltryptamine (DMT)	5-Methoxy-N,N-dimethyltryptamine	5-Methoxy-N,N-dimethyltryptamine
Characteristics	Rapid onset, vivid visual hallucinations, unhinged sense of time, potential for profound insights	Full-blown mystical or spiritual experiences, intense effects, rapid onset	Transformational, enhancing satisfaction with life, easing anxiety, depression, and PTSD symptoms
Potential Therapeutic Uses	Anxiety, depression, PTSD, substance use disorders	Anxiety, depression, PTSD, substance use disorders	Enhancement of satisfaction with life, easing anxiety, depression, and PTSD symptoms

The Future of DMT in Anxiety Treatment

Extended DMT use seems tolerable and possibly helpful for people with anxiety, presenting a different therapeutic approach from traditional methods.

Further research is necessary to understand how DMT works and its long-term effects. However, it shows promise as a new treatment for mental health issues, which offers hope to those battling anxiety and related disorders.

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Frequently Asked Questions

How do DMT vape carts work?

Vaping DMT is a straightforward process. These pens heat the DMT to its vaporization point, usually around 150-200°C (302-392°F). The user inhales the vapour released by the heating element, allowing the DMT to be absorbed into the bloodstream through the lungs.

Are there different types of DMT pens available?

Yes. Various types are available, from simple disposable models to more advanced rechargeable and refillable devices. Some pens are specifically designed for DMT, while others may be adapted for DMT concentrates.

Is a DMT vape safer than other methods of DMT consumption?

DMT vape pens are often considered safer than methods such as smoking or vaporizing DMT using traditional methods (e.g., using a glass pipe or foil). DMT vape cartridge offers better temperature control, reducing the risk of overheating and combustion, which can produce harmful by-products.

How do I use a DMT pen?

Charge Your Pen. Make sure the vape pen is fully charged.
Prepare. Choose a safe and comfortable place, ideally with someone sober with you.
Load DMT. If needed, put DMT into the pen’s heating chamber.
Turn On the Pen. Usually, pressing the power button five times activates the pen.
Set Temperature. Set the temperature suitable for DMT (around 140°C to 160°C) if possible.
Inhale. Take a slow inhale, hold the vapour for about 10-15 seconds, then exhale.
Repeat as Desired: Depending on your experience, you may or may not take more hits.
Turn Off and Clean: Always turn off the pen after use and clean it as instructed.